Sandee LaMotte, CNN
Sandee LaMotte, CNN
Based on new evidence assessing benefits and risks, WHO recommends the use of the HIV drug dolutegravir (DTG) as the preferred first-line and second-line treatment for all populations, including pregnant women and those of childbearing potential.
DTG is a drug that is more effective, easier to take and has fewer side effects than alternative drugs that are currently used. DTG also has a high genetic barrier to developing drug resistance.
Dementia is a group of diseases and conditions characterized by a reduction in memory, language, problem-solving and other thinking skills that affect a person’s ability to perform daily life activities. They also affect behaviour, feelings and relationships. The most common cause of dementia is Alzheimer’s disease.
Exercising, becoming more physically active and making other lifestyle changes could help people reduce their risk of dementia. Other lifestyle changes include:
Lifestyle changes to reduce the risk of a stroke or heart attack can also reduce the risk of dementia. Physiotherapists play an important role in supporting people age well. They offer advice to people about reducing the risk of dementia and are ideally placed to promote wellbeing activities such as exercise.
Researchers from Sri Venkateswara University, Tirupati, India, claim that black pepper contains an ingredient which could help fight against obesity.
Source: The times
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Eating processed meat may increase the risk of breast cancer by a fifth, state researchers from the University of Glasgow in the European Journal of Cancer.
Source:
The Times
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Scientists from King’s College London have revealed that hearing birdsong can boost mental wellbeing for more than four hours.
Source: Telegraph
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According to a study carried out in Brain Research using mice, Alzheimer’s disease could be treated with a diabetes drug.
Both conditions could be managed by a physiotherapist.
Source: Independent bit.ly/2D1tBok
Each year, one in five U.S. adults — an estimated 53 million people — experience harm because of someone else’s drinking, according to new research in the Journal of Studies on Alcohol and Drugs.
Similar to how policymakers have addressed the effects of secondhand smoke over the last two decades, society needs to combat the secondhand effects of drinking, the authors state, calling alcohol’s harm to others “a significant public health issue.”
According to the study — an analysis of U.S. national survey data — some 21% of women and 23% of men, an estimated 53 million adults, experienced harm because of someone else’s drinking in the last 12 months. These harms could be threats or harassment, ruined property or vandalism, physical aggression, harms related to driving, or financial or family problems. The most common harm was threats or harassment, reported by 16% of survey respondents.
The specific types of harm experienced differed by gender. Women were more likely to report financial and family problems, whereas ruined property, vandalism, and physical aggression were more likely to be reported by men.
There is “considerable risk for women from heavy, often male, drinkers in the household and, for men, from drinkers outside their family,” the authors write.
Additional factors, including age and the person’s own drinking, were also important. People younger than age 25 had a higher risk of experiencing harm from someone else’s drinking. Further, almost half of men and women who themselves were heavy drinkers said they had been harmed by someone else’s drinking. Even people who drank but not heavily were at two to three times the risk of harassment, threats, and driving-related harm compared with abstainers. Heavy drinking was defined as drinking five or more drinks at a time for men or four or more drinks for women at least monthly.
To conduct the study, researchers led by Madhabika B. Nayak, Ph.D., of the Alcohol Research Group, a program of the Public Health Institute in Oakland, Calif., analyzed data from two telephone surveys conducted in 2015 — the National Alcohol’s Harm to Others Survey and the National Alcohol Survey. The current research, funded by the National Institute on Alcohol Abuse and Alcoholism, looked at data from 8,750 respondents age 18 and older and provides support for alcohol control policies, such as taxation and pricing to reduce alcohol’s harm to persons other than the drinker.
The freedom to drink alcohol must be counter-balanced by the freedom from being afflicted by others’ drinking in ways manifested by homicide, alcohol-related sexual assault, car crashes, domestic abuse, lost household wages, and child neglect.”
Timothy Naimi, M.D., M.P.H., of the Boston Medical Center
Naimi advocates for increased taxes on alcoholic beverages, noting that there is strong evidence that increased alcohol taxes decrease excessive drinking and reduce the harms to people other than the drinker.
In a second commentary, Sven Andréasson, M.D., of the Karolinska Institutet of Stockholm, Sweden, writes, in a similar vein, that setting minimum prices for alcohol is important for reducing the harms caused by drinking.
“There is now a growing literature on the effects of national alcohol policies to reduce not only consumption but also some of the secondhand harms from alcohol, notably the effects of price policies on all forms of violence — assaults, sexual violence, partner violence, and violence toward children,” Andréasson writes. “Recent research on the effects of minimum pricing is particularly relevant in this context, where studies in Canada find reductions in violence after the introduction of minimum pricing.”
Nayak agrees. “Control policies, such as alcohol pricing, taxation, reduced availability, and restricting advertising, may be the most effective ways to reduce not only alcohol consumption but also alcohol’s harm to persons other than the drinker,” she says.
Nayak, M.B. et al. (2019) Alcohol’s Secondhand Harms in the United States: New Data on Prevalence and Risk Factors. Journal of Studies on Alcohol and Drugs. doi.org/10.15288/jsad.2019.80.273.
Reviewer:
James Ives, M.Psych. (Editor)Jul 1 2019
Researchers from the University of Copenhagen have learned that the effect of exercise may differ depending on the time of day it is performed. In mice they demonstrate that exercise in the morning results in an increased metabolic response in skeletal muscle, while exercise later in the day increases energy expenditure for an extended period of time.
We probably all know how important a healthy circadian rhythm is. Too little sleep can have severe health consequences. But researchers are still making new discoveries confirming that the body’s circadian clock affects our health.
Now, researchers from University of Copenhagen – in collaboration with researchers from University of California, Irvine – have learned that the effect of exercise may differ depending on the time of day it is performed. Studies in mice reveal that the effect of exercise performed in the beginning of the mouse’ dark/active phase, corresponding to our morning, differs from the effect of exercise performed in the beginning of the light/resting phase, corresponding to our evening.
There appears to be rather significant differences between the effect of exercise performed in the morning and evening, and these differences are probably controlled by the body’s circadian clock. Morning exercise initiates gene programs in the muscle cells, making them more effective and better capable of metabolizing sugar and fat. Evening exercise, on the other hand, increases whole body energy expenditure for an extended period of time.”
Associate Professor Jonas Thue Treebak from the Novo Nordisk Foundation Center for Basic Metabolic Research
The researchers have measured a number of effects in the muscle cells, including the transcriptional response and effects on the metabolites. The results show that responses are far stronger in both areas following exercise in the morning and that this is likely to be controlled by a central mechanism involving the protein HIF1-alfa, which directly regulates the body’s circadian clock.
Morning exercise appears to increase the ability of muscle cells to metabolize sugar and fat, and this type of effect interests the researchers in relation to people with severe overweight and type 2 diabetes.
On the other hand, the results also show that exercise in the evening increases energy expenditure in the hours after exercise. Therefore, the researchers cannot necessarily conclude that exercise in the morning is better than exercise in the evening, Jonas Thue Treebak stresses.
‘On this basis we cannot say for certain which is best, exercise in the morning or exercise in the evening. At this point, we can only conclude that the effects of the two appear to differ, and we certainly have to do more work to determine the potential mechanisms for the beneficial effects of exercise training performed at these two time-points. We are eager to extend these studies to humans to identify if timed exercise can be used as a treatment strategy for people with metabolic diseases’, he explains.
Source:
University of Copenhagen The Faculty of Health and Medical Sciences
Journal reference:
Sato, S. et al. (2019) Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis. Cell Metabolism. doi.org/10.1016/j.cmet.2019.03.013.
Reviewer:
Alina Shrourou, B.Sc. (Editor)Jun 13 2019